S1: Drug design and screening
Obligate intracellular parasites from the genus Plasmodium are the agents responsible for malaria, placing an estimated 3.4 billion people at risk of the disease throughout the world.
Scientists Against Malaria (SAM) was formed with the goal of designing novel antimalarial drug candidates.
Scoring molecules by similarity in fundamental 3D properties such as shape, chemical features and electrostatic potential has been a very productive method for hit discovery and lead hopping.
Plasmodium parasites boast a kinome with over 90 members, close to half of which are essential and therefore potential drug targets. They are also all S/T kinases...