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| About Chaohong Sun (Abbott) |
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Chaohong Sun received her PhD at Dartmouth College in 1998. She then came to Abbott Laboratories and worked as a post-doctoral fellow under Dr. Steve Fesik. Her PhD and postdoctoral works were focusing on using NMR to determine protein structures and to understand protein functions in combination with other biophysical tools. She was converted to a staff scientist at Abbott in 2000.
Currently, she is a Research Investigator in the Department of Structural Biology at the Global Pharmaceutical Research Division of Abbott Laboratories. Her research interest is focused on applying NMR to many aspects of the drug discovery process, from target characterization, fragment based screening for lead identification, to structure based drug design for lead optimization.
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NMR in target profiling and compound file enhancement
Chaohong Sun, Abbott Laboratories
NMR has matured as an important tool in drug discovery and development, with its roles in lead generation and optimization through NMR-based fragment screening and structure based drug design being well established. Besides these applications, NMR has expanded to make contributions both earlier and later in the drug discovery process. Here, the impact of NMR in the early stages of drug discovery will be presented, in particular in profiling targets and in using fragment hits in compound file-enhancement initiatives.
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