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- Biggin, P
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Dr. Michael Bolger is the Founding Scientist and Director of Life Sciences at Simulations Plus, Inc., Lancaster, California. He obtained a B.A. in Biology and Chemistry from UC San Diego in 1973 and his Ph.D. in Pharmaceutical Chemistry from UC San Francisco in 1978. From 1978-1980 he was an NIH Postdoctoral Fellow in pharmacology at the UC San Diego School of Medicine.
For the next 23 years, he was a professor of Pharmaceutical Sciences at USC School of Pharmacy, Los Angeles, California and he retired from USC in the spring of 2004. During this period he developed an interest in the computational aspects of drug design and drug development. As a faculty member at USC School of Pharmacy, his research was supported by several NIH basic science research grants and he published over 50 peer-reviewed publications. From 1989-1991 he served as a US Food and Drug Administration National Science Advisor. He is Chair of the AAPS Data Mining Focus Group, a member of the editorial board of Pharmaceutical Research and AAPS PharmSci, and has served as a reviewer for numerous scientific publications. He is currently Adjunct Associate Professor of Pharmaceutical Sciences at USC.
From 1987-1993, simultaneous with his academic duties, he was a founder and Director of Medicinal Chemistry at CoCensys Inc. There, he studied the chemistry and use of novel neuroactive steroids for treatment of anxiety, epilepsy, and sleep disorders. Drug candidates emanating from seven of Dr. Bolger’s patents have been tested in Phase I and II clinical trials for petite mal epilepsy, sleep disorders, and migraine.
Currently, he directs a team of scientist / programmers at Simulations Plus, Inc. (Lancaster, CA) in the development of software programs (ADMET Predictor, GastroPlus, ADMET Modeler, DDDPlus, and MembranePlus) for estimation of biopharmaceutical properties, simulations of absorption and bioavailability, automated generation QSP/AR model building, in vitro dissolution, and cell culture permeability simulation. He was elected to the rank of Fellow of the American Association for the Advancement of Science in 1996.
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